It made quite a difference for me. I have been using the same profile and preferences from about Firefox 2+ to 3.5.
Also:
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Also:
- Personas for Firefox messed up my forward and backward buttons.
- Enabling a master password for Firefox became a hassle when using TwitterFox. I had to enter my master password for every window that opened at startup.
- Something about my profile prevented some pages on t-mobile.com from redirecting properly. Firefox kept telling me that it was redirecting in a way that would never resolve. This was after I disabled all extensions.